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目的:香草醛(Vanlillin)作为一种重要的天然产物,具有镇静、抗惊厥、抗癫痫、治疗神经性头痛,抗菌等生物活性。通过分析了解香草醛的化学结构,改善香草醛中苯酚基易被氧化,易受空气影响的缺陷。方法:以天然D-木糖为原料经过乙酰化和溴代反应生成2,3,4-三-O-乙酰-a-D-溴代吡喃木糖。再与香草醛反应生成4-甲酰基-2-甲氧基-苯基-2,3,4-三-O-乙酰-β-D-吡喃木糖苷,通过熔点及薄层鉴定确定该化合物的结构。结论:此化合物提高了香草醛的稳定性和生物活性,且合成利于筛选更高抗菌活性的药物。
OBJECTIVE: Vanlillin, as an important natural product, has the biological activity of sedation, anticonvulsant, antiepileptic, neuropathic headache and antibacterial activity. By analyzing and understanding the chemical structure of vanillin, vanillin can be easily oxidized and easily affected by air. Methods: Natural D-xylose was acetylated and brominated to produce 2,3,4-tri-O-acetyl-a-D-bromopyranosylose. Then reacted with vanillin to form 4-formyl-2-methoxy-phenyl-2,3,4-tri-O-acetyl-β-D-xylopyranoside. The compound was identified by melting point and TLC Structure. Conclusion: This compound enhances the stability and biological activity of vanillin, and the synthesis of drugs for screening higher antibacterial activity.