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目的:探讨孕激素受体(PR)和雌激素受体(ER)表达与子宫内膜癌病情的相关性。方法:将30例非子宫内膜癌患者(A组)及60例子宫内膜癌患者(B组)作为观察对象,对比两组子宫组织内PR及ER表达阳性率。同时将子宫内膜癌患者按照病理分为28例的Ⅰ期组、18例的Ⅱ期组及14例的Ⅲ期组。分别对比不同分期子宫内膜癌患者间PR及ER表达阳性率。并对PR及ER表达阳性率与子宫内膜癌分期的相关性进行分析。结果:B组PR及ER表达阳性率明显高于A组(P<0.05);且子宫内膜癌不同分期的三组间PR及ER表达阳性率同样存在显著的统计学差异,以Ⅲ期组PR及ER表达阳性率最高(P<0.05)。此外,PR及ER表达阳性率与子宫内膜癌分期存在显著的正向直线相关性(P<0.05)。结论:子宫内膜癌患者体内PR及ER表达阳性率明显升高,且PR及ER表达阳性率与分期存在显著相关性。
Objective: To investigate the relationship between the expression of progesterone receptor (PR) and estrogen receptor (ER) and the severity of endometrial cancer. Methods: Thirty patients with non-endometrial carcinoma (group A) and 60 patients with endometrial carcinoma (group B) were observed. The positive rates of PR and ER in the two groups were compared. At the same time, patients with endometrial cancer were divided into two groups according to the pathology: stage Ⅰ group (28 cases), stage Ⅱ group (18 cases) and stage Ⅲ group (14 cases). The positive rates of PR and ER expression in patients with different stages of endometrial cancer were compared. The correlation between the positive rate of PR and ER and the staging of endometrial cancer was analyzed. Results: The positive rates of PR and ER in group B were significantly higher than those in group A (P <0.05). There was also a significant difference in the positive rates of PR and ER between the three groups at different stages of endometrial cancer. PR and ER expression was the highest (P <0.05). In addition, there was a significant positive linear correlation between the expression of PR and ER and the staging of endometrial cancer (P <0.05). Conclusion: The positive rate of PR and ER expression in endometrial carcinoma patients was significantly increased, and the positive rate of PR and ER were significantly correlated with the stage.