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７．５～６０ｍｇ／Ｌ卡介苗（ＢＣＧ）刺激的肺泡巨噬细胞（ＰＡＭ）培养上清液能显著促进肺成纤维细胞（ＰＦＢ）增殖和胶原合成。发现该上清液中含较高水平的肿瘤坏死因子（ＴＮＰ），且其促ＰＦＢ增殖作用与ＴＮＦ水平成正相关，提示ＢＣＧ在体外能刺激ＰＡＭ产生ＴＮＦ，ＴＮＦ为该上清液促ＰＦＢ增殖的主要因素；５０ｍｇ／ＬＳｉＯ２刺激的ＰＡＭ上清液亦能促进ＰＦＢ增殖和胶原合成，但上清液中几乎检测不到ＴＮＦ，说明其促ＰＦＢ增殖和胶原合成的成分是不同于ＴＮＦ的其它物质；ＴＮＦ能协同该物质促ＰＦＢ增殖和胶原合成。上述结果提示，结核菌刺激ＰＡＭ产生ＴＮＰ可能是矽肺结核病较单纯矽肺发展迅速的一个重要原因。
The supernatant of alveolar macrophages (PAM) stimulated with BCG at 7.5 ~ 60mg / L could significantly promote the proliferation and collagen synthesis of pulmonary fibroblasts (PFB). This supernatant was found to contain a high level of tumor necrosis factor (TNP), and its pro-proliferative effect on PFB was positively correlated with TNF level, suggesting that BCG can stimulate the production of TNF in vitro by TNF and TNF as the supernatant to promote the proliferation of PFB Of the main factors; 50mg / LSiO2-stimulated PAM supernatant also can promote the PFB proliferation and collagen synthesis, but the supernatant was almost undetectable TNF, indicating that the pro-PFB proliferation and collagen synthesis of the composition is different from other substances of TNF ; TNF can cooperate with this material to promote PFB proliferation and collagen synthesis. These results suggest that tuberculosis stimulate TNP production TN may be more serious than silicosis of silicosis is an important reason for the rapid development of silicosis.