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血栓调节蛋白(TM)是血管内皮细胞膜表面的一种糖蛋白,在辅助 C 蛋白的凝血酶催化活性中起重要作用。TM 能抑制凝血酶的促凝血活性,例如抑制纤维蛋白形成,抑制 V、Xa 因子和血小板活性使凝血酶的促凝血作用转化为抗凝血物质,以调节血管内的凝血过程。一些学者认为,微量白蛋白尿常是广泛血管病变的预报。本文旨在研究糖尿病患者血浆 TM 浓度与白蛋白尿、血管疾病的关系。病人和方法非胰岛素依赖型糖尿病患者67例,年龄30～69(平均57±10)岁,平均病程12±6(范围1～28)年,男性39例、女性28例,伴不同程度的微量白蛋白尿。正常入34名为对照组,年龄55±10
Thrombomodulin (TM), a glycoprotein on the surface of vascular endothelial cells, plays an important role in assisting the catalytic activity of thrombin of protein C. TM inhibits the procoagulant activity of thrombin, for example, inhibits fibrin formation, suppresses factor V and factor Xa, and platelet activity converts the procoagulant effect of thrombin to an anticoagulant to regulate the intravascular coagulation process. Some scholars believe that microalbuminuria is often a predictor of extensive vascular disease. This article aims to study the relationship between plasma TM concentration and albuminuria and vascular diseases in diabetic patients. Patients and Methods A total of 67 patients with non-insulin-dependent diabetes mellitus aged 30 to 69 years (mean 57 ± 10 years) with an average duration of 12 ± 6 (range, 1 to 28) years, 39 males and 28 females with varying degrees of micro- Albuminuria. Normal into 34 as a control group, age 55 ± 10