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目的观察应用质子泵抑制剂(PPI)患者,在强效抑酸状态下小肠细菌过生长(SIBO)的发生情况。方法用葡萄糖呼气H2试验,检测57例服用PPI制剂患者,30名健康志愿者作为对照。结果 PPI制剂组中呼气H2检测SIBO阳性28例,阴性29例;健康对照组中SIBO阳性3例,阴性27例。PPI组与健康对照组比较差异有统计学意义(P<0.01),PPI制剂使用时间与SIBO阳性率存在正相关性。结论长期服用PPI制剂的患者可并发SIBO,且SIBO的发病率与PPI制剂使用时间呈正相关。
Objective To observe the incidence of intestinal bacterial overgrowth (SIBO) in patients with proton pump inhibitor (PPI) under potent acid suppression. Methods H2O2 glucose breath test, detection of 57 patients taking PPI preparations, 30 healthy volunteers as a control. Results There were 28 cases of SIBO positive and 29 cases negative in exhaled H2 in PPI preparation group, 3 cases of SIBO positive and 27 cases negative in healthy control group. The difference between PPI group and healthy control group was statistically significant (P <0.01). There was a positive correlation between the use time of PPI and the positive rate of SIBO. Conclusions SIBO may be complicated by long-term PPI dosage. The incidence of SIBO is positively correlated with the duration of PPI preparation.