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目的:探讨自配漱口液治疗放疗所致口腔黏膜反应的效果。方法:以本科2006年1月至2010年5月收治的头颈部恶性肿瘤在本科放疗的32例患者作为实验组,除常规口腔护理外,从放疗开始每天于放疗前和进食前后预防性地含漱自配漱口液,直至放疗结束后10d。另选同期头颈部恶性肿瘤放疗患者32例作为对照组,对照组在整个放疗期间进行常规口控护理,保持口腔卫生,每日于放疗前及进食前后以氧化电位水漱口,必要时行雾化吸入。监测两组放疗期间口腔酸碱度和唾液分泌量变化,记录患者进食情况,口腔黏膜变化,吞咽疼痛与放疗剂量的关系等。最后比较两组发生口腔黏膜反应的程度。结果:放疗至30Gy时,两组疗效对比无统计学意义(P>0.05),放疗至60Gy及放疗结束后10d,实验组3～4级黏膜反应明显少于对照组(P<0.01);实验组唾液分泌量及唾液pH值大于对照组,不良反应也较对照组轻。结论:自配漱口液有消炎、止痛、减轻水肿等作用,可用于综合防治放射性口腔黏膜反应,为患者完成放疗创造条件。
Objective: To investigate the effect of gargle with mouthwash on oral mucosal reaction induced by radiotherapy. Methods: Thirty-two patients with malignant head and neck cancer underwent radiotherapy from January 2006 to May 2010 were selected as the experimental group. In addition to routine oral care, Gargle with gargle, until 10d after the end of radiotherapy. In the same period, 32 patients with radiotherapy of head and neck malignant tumor were selected as the control group. The control group received routine oral control during the whole radiotherapy to maintain oral hygiene. Gargle with oxidative potential water before and after radiotherapy daily and if necessary aerosol inhalation. The changes of oral pH and salivary secretion during the two groups were monitored. The patient’s food intake, oral mucosal changes, the relationship between swallowing pain and radiation dose were recorded. Finally, the degree of occurrence of oral mucosal reaction in both groups was compared. Results: There was no significant difference between the two groups in radiotherapy (P> 0.05). The radiotherapy to 60Gy and radiotherapy 10d after the end of the reaction, the experimental group 3 to 4 mucosal response was significantly less than the control group (P <0.01); experiment Group saliva secretion and saliva pH value greater than the control group, adverse reactions were lighter than the control group. Conclusion: Self-formulated gargle has anti-inflammatory, analgesic and edema-reducing effects. It can be used in the prevention and treatment of radiation-induced oral mucosal reaction and create conditions for patients to complete radiotherapy.