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为探讨冬虫夏草(以下简称虫草)对白血病的作用及抑癌机制,观察了虫草水提液对正常人及白血病患者外周血NK细胞的影响,发现虫草可提高正常人及白血病NK细胞活性,在所使用的剂量范围内(1.56～25mg/ml)呈剂量-效应依赖性(r=0.984,P<0.01;r=0.988,P<0.01)。同时发现虫草可促进淋巴细胞表面CD_(16)抗原的表达,提高与K_(562)细胞的结合率。毒性试验表明对血细胞无毒性作用。认为虫草作为生物反应调节剂用于急性白血病治疗以提高NK细胞活性,值得进一步研究、开发与利用。
To investigate the effect of Cordyceps sinensis on leukemia and the mechanism of tumor suppressor, the effect of Cordyceps sinensis water extract on peripheral blood NK cells in normal people and leukemia patients was observed. It was found that Cordyceps sinensis can increase the activity of normal and leukemia NK cells. The dose range used (1.56-25 mg/ml) was dose-effect dependent (r=0.984, P<0.01; r=0.988, P<0.01). At the same time, it was found that Cordyceps can promote the expression of CD_(16) antigen on lymphocytes and increase the binding rate to K_(562) cells. Toxicity tests showed no toxic effects on blood cells. Cordyceps sinensis is considered as a biological response regulator for the treatment of acute leukemia in order to increase the activity of NK cells and is worthy of further research, development and utilization.