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目的探讨新疆老年男性骨转换生化标志物及性激素水平与原发性骨质疏松症的关系。方法采用双能X线骨密度仪检测146例老年男性患者腰椎、左侧股骨骨密度(BMD),平均年龄:72.4±7.9岁,基于骨密度T值分为骨量正常组(75例)和骨量异常组(71例),采用酶联免疫法测定Ⅰ型前胶原氨基端原肽(PINP)和Ⅰ型胶原C末端肽(CTX),放射免疫法测定雌二醇(E2)和睾酮(T),比较两组骨转换生化指标和性激素水平是否存在差异及其与骨密度的相关性。结果 1 PINP与CTX在骨量正常组和骨量异常组差异均无统计学意义(P>0.05);两者偏相关分析呈显著正相关(r=0.746 P=0.000)。2雌二醇、睾酮在两组中比较,差异有统计学意义(P<0.05)。骨量异常组雌二醇(17.48±7.61)低于骨量正常组(21.31±11.43),t=2.391,P=0.018;骨量异常组睾酮(3.50±1.02)低于骨量正常组(3.98±1.43),t=2.331,P=0.021。3汉族人群左侧髋关节骨密度高于维吾尔族人群,除Inter Tro部位外,差异均有统计学意义(P<0.05);年龄与髋关节各部位骨密度呈显著负相关。结论性激素水平降低可能是影响男性骨量减少的一个重要危险因素,而雌激素可能占主要地位;随着年龄的增加,老年男性髋关节骨密度呈下降趋势,测定左侧髋关节骨密度对诊断骨质疏松症有着重要意义。
Objective To investigate the relationship between bone turnover biochemical markers and sex hormone levels and primary osteoporosis in elderly men in Xinjiang. Methods The BMD of lumbar spine and left femur were measured by dual-energy X-ray absorptiometry in 146 elderly male patients. The average age was 72.4 ± 7.9 years old. The bone mineral density (T value) was divided into normal group (75 cases) and (N = 71). The levels of type Ⅰ procollagen aminopeptidase (PINP) and type Ⅰ collagen C terminal peptide (CTX) were determined by enzyme-linked immunosorbent assay (ELISA) T), and to compare the biochemical markers of bone turnover and sex hormone levels differences between the two groups and its correlation with bone mineral density. Results There was no significant difference between PINP and CTX in normal bone mass group and abnormal bone mass group (P> 0.05). There was a significant positive correlation between PINP and CTX (r = 0.746 P = 0.000). 2 estradiol, testosterone in the two groups, the difference was statistically significant (P <0.05). The skeletal abnormalities in the group of estradiol (17.48 ± 7.61) were lower than those in the normal group (21.31 ± 11.43, t = 2.391, P = 0.018) ± 1.43), t = 2.331, P = 0.021. The left hip hip BMD of Han nationality was higher than that of Uygur population except for Inter Tro site (P <0.05) The bone mineral density was significantly negatively correlated. Conclusions The decrease of sex hormones may be an important risk factor to affect the osteopenia in males, and estrogen may be the main factor. With the increase of age, the hip BMD of elderly men shows a decreasing trend. The left hip BMD Osteoporosis is of great importance.