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目的:观察决明子水溶物对四氯化碳所致小鼠急性肝损伤的保护作用。方法:将50只小鼠随机的分为正常组、阳性对照组、四氯化碳模型组、决明子大剂量组和决明子小剂量组,每组各10只。采用四氯化碳复制小鼠急性肝损伤模型,并给予决明子水溶物灌胃,对照组小鼠不做处理。测定各组小鼠体内丙氨酸氨基转移酶活性、血清天冬氨酸转苷酶和丙二醛的含量以及谷胱甘肽过氧化物酶活性。结果:决明子水溶物可以显著降低四氯化碳所致急性肝损伤模型小鼠血清丙氨酸氨基转移酶和天冬氨酸转苷酶活性,同时降低小鼠肝组织丙二醛的含量,升高肝组织谷胱甘肽过氧化物酶的活性。结论:决明子水溶物四氯化碳所致急性肝损伤小鼠具有保护作用。
Objective: To observe the protective effect of cassia seed water soluble substance on carbon tetrachloride-induced acute liver injury in mice. Methods: Fifty mice were randomly divided into normal group, positive control group, carbon tetrachloride model group, high dose of Cassia seed and small dose of Cassia seed, 10 in each group. Carbon tetrachloride (CCl4) was used to replicate the model of acute liver injury in mice, and gavage was given to Cassia toxin. Mice in control group were not treated. The alanine aminotransferase activity, serum aspartate aminosidase and malondialdehyde content and glutathione peroxidase activity in each group were measured. Results: Soluble Cassia seed could significantly reduce the activity of alanine aminotransferase and aspartase in serum of acute liver injury model induced by carbon tetrachloride, reduce the content of malondialdehyde High hepatic glutathione peroxidase activity. Conclusion: The cassia seed water-soluble carbon tetrachloride-induced acute liver injury in mice has a protective effect.