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本文报道抗疟药羟氯喹(HCQ)与甲氨蝶呤(MTX)联合治疗类风湿性关节炎(RA)患者61例,并与MTX单用比较,以观察其疗效和安全性。1资料与方法1.1病例选择118例临床确诊为活动期RA患者,均符合美国风湿病协会1987年制订的RA诊断标准。MTX+HCQ联合治疗组61例,MTX组57例,观察24周。全部病例均排除严重心、肝、肾等功能不全者,有活动性胃肠病变者,血液及内分泌系统疾病者,过敏体质者,孕期或哺乳期妇女,以及3周内用过激素或其他DMARDs者。1.2治疗方法MIX+HCQ联合治疗组:MTX10mg/周,
This article reports 61 cases of rheumatoid arthritis (RA) treated with HCQ combined with methotrexate (MTX) and compared with MTX alone to observe its efficacy and safety. 1 Materials and Methods 1.1 Case Selection 118 cases of clinically diagnosed active RA patients, all in line with the American Rheumatism Association in 1987 developed RA diagnostic criteria. MTX + HCQ combined treatment group of 61 cases, 57 cases of MTX group, observed for 24 weeks. All cases were excluded severe heart, liver, kidney and other dysfunction, active gastrointestinal disease, blood and endocrine system diseases, allergies, pregnant or lactating women, and within 3 weeks with hormone or other DMARDs By. 1.2 Treatment MIX + HCQ combined treatment group: MTX10mg / week,