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缺氧诱导因子 (HIF 1)是一个基本的循环转录因子 ,当哺乳动物细胞在缺氧、红细胞生成素(EPO)和血管内皮生长因子 (VEGF)或一些蛋白基因转录激活时被表达。它在维持氧稳态时起着非常重要的作用。当前的研究也为 HIF 1在调节一些糖酵解酶的基因编码方面提供了证据 ,另外还有证据表明HIF 1可以通过抑制糖异生的过程促进糖酵解的进行。通过描述葡萄糖糖载体蛋白 1(GL UF 1)、磷酸果糖激酶 (PFKL)、醛缩酶 (AL DA)、磷酸甘油酸酶 (PGK1)、烯醇酶 (ENO1)、丙酮酸激酶 (PKM)、乳酸脱氢酶(L DHA)的基因启动子作为低氧反应元件和 HIF 1结合并受 HIF 1激活 ,HIF 1在诱导糖酵解酶的基因表达过程中的作用 ,从而阐明了 HIF 1在激活这些元件和促进糖酵解过程中是必须的。
Hypoxia-inducible factor (HIF 1) is a basic circulatory transcription factor that is expressed when mammalian cells are transcriptionally activated by hypoxia, erythropoietin (EPO), and vascular endothelial growth factor (VEGF) or some protein genes. It plays a very important role in maintaining oxygen homeostasis. Current research also provides evidence that HIF 1 regulates the gene coding of some glycolytic enzymes and there is also evidence that HIF 1 promotes glycolysis by inhibiting gluconeogenesis. By describing the phosphorylation of glucose transporter 1 (GLUF 1), phosphofructokinase (PFKL), aldolase (AL DA), phosphoglycerate (PGK1), enolase (ENO1), pyruvate kinase (PKM) The gene promoter of lactate dehydrogenase (L DHA) acts as a hypoxia response element that binds to HIF 1 and is activated by HIF 1, and HIF 1 plays a role in inducing the gene expression of glycolytic enzymes, thus clarifying the role of HIF 1 in activating These elements and promote glycolysis process is necessary.