论文部分内容阅读
一、纤维粘连蛋白的化学与功能纤维粘连蛋白(Fibronectin,Fn)是一种非胶原性精蛋白,约含糖5％,pI为5.5～6.3,广泛存在于血浆(300μg/ml)、组织间液、细胞外基质及基底膜。它的存在形式有两种,一种是血浆Fn,生理状态呈可溶性,在低温时则为不溶性,故又称为冷凝蛋白(cool insoluble protein);另一种为细胞Fn,呈不溶性,除巨噬细胞、软骨细胞、羊膜细胞、肠上皮细胞及乳腺上皮细胞能少量合成外,主要由纤维母细胞及内皮细胞生成。二类Fn在pI及可溶性上有些不同,其它的化学性质基本相似。
First, the chemical and functional fibronectin Fibronectin (Fn) is a non-collagenous protamine, about 5% sugar, pI is 5.5 ~ 6.3, widely present in plasma (300μg/ml), between tissues Fluid, extracellular matrix, and basement membrane. It exists in two forms, one is plasma Fn, which is soluble in physiological state, and insoluble at low temperatures, so it is also called cool insoluble protein; the other is cell Fn, insoluble, except giant Phagocytes, chondrocytes, amnion cells, intestinal epithelial cells, and mammary epithelial cells can be synthesized in small amounts, mainly by fibroblasts and endothelial cells. The two types of Fn have some differences in pI and solubility, and other chemical properties are basically similar.