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Pluronic P123(P123)是泊洛沙姆类聚合物中的一种,具有增加水难溶性药物的溶解度、延长体内循环时间、增加药物的细胞内摄取、抑制肿瘤的迁移、逆转多药耐药和增强药物的疗效等作用,在递送药物方面具有众多优势。通过对P123末端羟基的结构修饰,P123能以酯键、酰胺键和糖苷键等化学键与其他物质结合而生成新的材料,用以制备Pluronic P123-药物结合物胶束体系、配体介导的主动靶向转运系统及其他药物递送系统,增加药物或基因向靶组织的递送。本文综述了结构修饰后的P123在药物递送方面的应用。
Pluronic P123 (P123) is a poloxamer-based polymer that has the potential to increase the solubility of poorly water-soluble drugs, prolong circulation in vivo, increase intracellular uptake of drugs, inhibit tumor migration, reverse multidrug resistance and Enhance the efficacy of drugs and other effects, in the delivery of drugs has many advantages. Through structural modification of the terminal hydroxyl group of P123, P123 can bond with other substances through chemical bonds such as ester bonds, amide bonds and glycosidic bonds and generate new materials for preparing Pluronic P123-drug conjugate micellar systems, ligand-mediated Proactive targeting of transport systems and other drug delivery systems increases the delivery of drugs or genes to target tissues. This review summarizes the application of structurally modified P123 in drug delivery.