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目的观察拉米夫定联合膈下逐瘀汤治疗乙型肝炎肝硬化的效果,以改善肝功能。方法选取2009年1月50例乙型肝炎肝硬化患者,分为治疗组与对照组,各25例;治疗组应用拉米夫定联合膈下逐瘀汤治疗;对照组单用拉米夫定进行治疗;观察并比较两组在治疗前后肝功能、肝纤维化指标、门静脉血流动力学、血清HBV-DNA等,并进行Child-Pugh分级评分,应用SPSS13.0软件进行统计分析。结果经过治疗两组患者的肝功能指标明显改善,肝纤维化指标有所下降,门静脉血流动力学的指标也明显改善,HBV-DNA载量下降,Child-Pugh评分有所下降,对照组由(9.3±2.6)分降至(6.2±2.1)分;与对照组相比,治疗组在以上各项指标的改善均更加明显,Child-Pugh评分治疗组为(6.2±2.1)分,对照组为(8.1±2.4)分,差异均有统计学意义(P<0.05)。结论拉米夫定联合膈下逐瘀汤治疗乙型肝炎肝硬化的效果更加明显,优于单用拉米夫定。
Objective To observe the effect of Lamivudine combined with Gexia Zhuyu Decoction in treating hepatitis B cirrhosis and improve liver function. Methods Fifty patients with hepatitis B cirrhosis were selected from January 2009 and divided into treatment group and control group, with 25 cases in each group. The treatment group was treated with lamivudine combined with Xiaxia Zhuyu Decoction. The control group received lamivudine alone The liver function, liver fibrosis index, portal vein hemodynamics, serum HBV-DNA, etc. were observed and compared before and after treatment. Child-Pugh grading was used to analyze the data. SPSS13.0 software was used for statistical analysis. Results After treatment, the indexes of liver function of the two groups were significantly improved, the indicators of hepatic fibrosis decreased, the indices of portal hemodynamics were significantly improved, the HBV-DNA load was decreased and Child-Pugh score was decreased. The control group consisted of (9.3 ± 2.6) points to (6.2 ± 2.1) points. Compared with the control group, the improvement of the above indexes in the treatment group was more obvious. The Child-Pugh score was (6.2 ± 2.1) in the treatment group and the control group (8.1 ± 2.4) points, the differences were statistically significant (P <0.05). Conclusion lamivudine combined with Gexia Zhuyu Tang treatment of hepatitis B cirrhosis more effective than lamivudine alone.