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目的:探讨热性惊厥与佝偻病的相关性。方法:选取2009年1月～2011年12月我院门诊/住院3月～3岁儿童120名作为研究对象,其中热性惊厥组、发热组和正常对照组各40例,检测和比较三组佝偻病患病率及其体内血钙、25-(OH)-D3、碱性磷酸酶及骨密度指标。结果:热性惊厥组佝偻病发病率显著高于较对照组及发热组,P均<0.01,且处于活动期佝偻病患儿数目也较其他两组多;热性惊厥组血钙、25-(OH)-D_3、碱性磷酸酶及骨密度显著低于对照组及发热组,P均<0.05,而血清碱性磷酸酶浓度则显著高于对照组及发热组,P<0.01和P<0.05。结论:热性惊厥患儿佝偻病患病率及佝偻病相关指标异常程度增高,热性惊厥与佝偻病存在一定相关性。
Objective: To investigate the correlation between febrile seizures and rickets. Methods: Totally 120 children aged 3 months to 3 years in our hospital from January 2009 to December 2011 were enrolled in this study. Forty patients in each of febrile seizure group, fever group and normal control group were enrolled in the study. The prevalence of rickets and its serum calcium, 25- (OH) -D3, alkaline phosphatase and bone mineral density indicators. Results: The incidence of rickets in the febrile seizures group was significantly higher than that in the control group and fever group (P <0.01), and the number of children with active rickets was more than that in the other two groups. The levels of serum calcium and 25- (OH) ) -D_3, alkaline phosphatase and bone mineral density were significantly lower than the control group and fever group, P <0.05, while serum ALP levels were significantly higher than the control group and fever group, P <0.01 and P <0.05. Conclusion: The prevalence of rickets and rickets in children with febrile seizures are higher than those in rickets, and there is a correlation between febrile seizures and rickets.