继从喜树(Camptotheca acuminata Decne)果中分到二十余个化合物之后,最近又从广西河池地区综合研究所生产10-羟基喜树碱的母液中分得了新生物碱10-羟基脱氧喜树碱(1)。 1为黄色针晶,m.p.298—300℃(分解),[α]_D~(16)—9.36°(c0.086,吡啶),分子式C_(20)H_(16)N_2O_4,与喜树碱(2)相同,比10-羟基喜树碱(3)少一个氧原子。薄层层析R_f=0.3[硅胶层,7:3氯仿-丙酮(v/v)],稍大于3(R_f=0.2),但远小于2(R_f=0.7)在3650A荧光下,1、3均为米黄色 Following the distribution of more than twenty compounds from the Camptotheca acuminata Decne fruit, a new alkaloid 10-hydroxydeoxycamptothene was recently obtained from the mother liquor of 10-hydroxycamptothecin produced by the Comprehensive Research Institute of Hechi, Guangxi. Alkali (1). 1 is a yellow needle, mp298-300°C (decomposition), [α]_D~(16)-9.36° (c0.086, pyridine), molecular formula C_(20)H_(16)N_2O_4, and camptothecin ( 2) Same, one oxygen atom less than 10-hydroxycamptothecin (3). Thin layer chromatography R_f = 0.3 [silica gel layer, 7:3 chloroform-acetone (v/v)], slightly more than 3 (R_f = 0.2), but much less than 2 (R_f = 0.7) under fluorescence of 3650A, 1, 3 Are beige