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目的：研究被动吸烟对儿童体内谷胱甘肽过氧化物酶活力（GSH－PX）及维生素C（VitC）的影响。方法：以整群抽样的方法调查了964名儿童，从中筛选出家中无吸烟者、家中一人吸烟及两人以上吸烟儿童各20名。为避免主观误差，我们以尼古丁代谢产物可铁宁作为吸入烟雾多少的客观指标，同时测定血清中谷胱甘肽过氧化物酶活力及尿中维生素C含量。结果：可铁宁与被动吸烟量直接相关。而GSH－PX及VitC随着吸入烟雾浓度的增加而逐渐减少，差异有显著性（P＜0．01）。结论：被动吸烟可致儿童体内GSH－PX活力下降及尿中VitC含量减少。
Objective: To study the effects of passive smoking on glutathione peroxidase (GSH-PX) and vitamin C (vitamin C) in children. METHODS: A total of 964 children were enrolled in a cluster sampling study to screen out 20 non-smokers, 1 smokers and 2 smokers at home. In order to avoid subjective error, we nicotine metabolites cotinine as an objective indicator of how much smoke inhalation, and determination of serum glutathione peroxidase activity and urinary vitamin C content. Results: Corotinine was directly related to the amount of passive smoking. GSH-PX and VitC gradually decreased with the increase of inhaled smoke concentration (P <0.01). Conclusion: Passive smoking can lead to the decrease of GSH-PX activity and the decrease of urinary VitC content in children.