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唇裂患者绝大部分为婴幼儿,抗生素在其体内的药代动力学过程与成人不同。婴幼儿胃酸偏低,体内酶系统尚未成熟,另外血浆蛋白与药物结合力弱,血药游离浓度较高,肾功能未发育完善,对抗生素排泄缓慢,半衰期延长易于中毒。本文所指的合理用药是兼具安全性、有效性、经济型和适当性四大要素。作者收集96例婴幼儿唇裂患者,采用不同的围手术期给药方式,并从不同方面观察得知,术前半小时及术后48h内短程使用抗生素,与长期术后使用抗生素来预防感染对伤口预后效果差异无统计学意义。
The vast majority of cleft lip patients are infants and young children, antibiotics in their body pharmacokinetic process and adults are different. Infants with low gastric acid, the body enzyme system is not yet mature, in addition to plasma protein and drug binding is weak, higher free blood concentration, renal function is not well developed, slow excretion of antibiotics, half-life prolonged susceptible to poisoning. This article refers to the rational use of drugs is both safe, effective, economical and appropriate four elements. The authors collected 96 cases of infant patients with cleft lip, using different perioperative modes of administration, and from different aspects of observation that half an hour before and after 48h short-range antibiotics, and long-term use of antibiotics to prevent infection on the wound No significant difference in prognosis.