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目的:观察丹皮酚对异烟肼和利福平肝毒性的保护作用。方法:分别测定肝损害组和丹皮酚大、中、小剂量组小鼠的SGPT、肝指数、肝匀浆丙二醛(MDA)含量、肝微粒体P450和线粒体Ca~(2+)ATP酶活性,以及肝病理学检查,并与对照组比较。结果:丹皮酚大、中、小剂量均可对抗异烟肼和利福平引起SGPT增高(P<0.05)、线粒体Ca~(2+)ATP酶活性的降低以及对抗其引起的形态学改变;对MDA的升高也有对抗作用,但只在大剂量组差异才有显著性;小剂量的丹皮酚对肝药酶有诱导作用,但差异无显著性(P>0.05),大剂量则可对抗利福平的诱导作用。
Objective: To observe the protective effect of paeonol on hepatotoxicity of isoniazid and rifampin. METHODS: SGPT, liver index, liver homogenate malondialdehyde (MDA) content, hepatic microsomal P450 and mitochondrial Ca 2+ ATP were determined in hepatic injury group and paeonol large, medium and low dose groups, respectively. Enzyme activity, as well as liver pathology, were compared with the control group. RESULTS: Large, medium, and small doses of paeonol increased SGPT (P<0.05), mitochondrial Ca~(2+) ATPase activity, and morphological changes caused by it against isoniazid and rifampin. There is also an antagonistic effect on the elevation of MDA, but it is significant only in the high-dose group; small doses of paeonol have an induction effect on hepatic enzymes, but the difference is not statistically significant (P>0.05). It can fight the induction of rifampicin.