【摘 要】
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Many small-molecule compounds were reported as microtubule-inhibitor with potential anticancer activities,such as combretastatin-A4(CA-4)analogue.The title comp
【机 构】
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Department of Pharmacy,General Hospital of Shenyang Military Command,Shenyang 110016,China“,”Departm
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Many small-molecule compounds were reported as microtubule-inhibitor with potential anticancer activities,such as combretastatin-A4(CA-4)analogue.The title compound which is one novel cyclopropylamide analogue of CA-4,namely as ethyl 1-((2-bromophenyl)car-bamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate,has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction.The crystal belongs to monoclinic,space group P21/n with a = 8.8002(6),b = 1 1.4525(8),c = 21.7870(16)(A),β= 93.810(3)°,v=2190.9(3)(A)3,Z = 4,C22H23BrNO6,Mr = 477.32,Dc = 1.447 Mg/cm3,F(OOO)= 980,(λ)(CuKα)=1.54178(A),μ= 2.883 mm-1,R= 0.0691 and wR= 0.1958 for 6420 observed reflections(I＞2(σ)(I)).Importantly,the compound revealed potential anticancer activities in six cancer cells and could stimulate tubulin polymerization in vitro,indicating that the small-molecule could be selected as a lead compound for the development of microtubule stimulator.
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