论文部分内容阅读
应用免疫组织化学Ｓ·Ｐ法检测了４２例胆囊腺癌和８例胆囊腺瘤中ｐ５３蛋白（突变型）的表达情况。结果显示，胆囊腺癌中ｐ５３阳性率为４７．６％，胆囊腺瘤及癌旁正常粘膜阳性率均为０％，与胆囊腺癌比较，差异有显著性（Ｐ＜０．００５）。ｐ５３在胆囊低分化腺癌中阳性表达率明显高于高分化腺癌（Ｐ＜０．０５），ｐ５３基因的突变或过表达是胆囊腺癌发生发展过程中常见的基因事件，ｐ５３蛋白的过表达可能预示着较差的预后
Immunohistochemical SP method was used to detect the expression of p53 protein (mutant) in 42 cases of gallbladder adenocarcinoma and 8 cases of gallbladder adenoma. The results showed that the positive rate of p53 in gallbladder adenocarcinoma was 47.6%, and the positive rate of gallbladder adenoma and adjacent normal mucosa was 0%. Compared with gallbladder adenocarcinoma, the difference was statistically significant (P<0.005). The positive expression rate of p53 in poorly differentiated adenocarcinoma of gallbladder was significantly higher than that of well-differentiated adenocarcinoma (P<0.05). The mutation or overexpression of p53 gene is a common gene event during the development of gallbladder adenocarcinoma. Expression may indicate poor prognosis