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目的观察分析尿微量蛋白及血清胱抑素C在糖尿病肾病中的应用价值。方法按照知情同意原则分别选取我院2010年3月至2012年10月收治的73例糖尿病患者和73例健康的体检者,组成观察组和对照组。对两组中的所有患者均进行取晨尿测尿微量蛋白、空腹抽血并用胶乳增强免疫比浊法检测血清胱抑素C,并准确记录,最后对结果进行对比分析。结果比较两组成员的血清胱抑素含量(t=7.8147,P<0.05)和尿微量白蛋白含量(t=147.2285,P<0.05),差异有统计学意义(P<0.05)。结论血清胱抑素C以及尿微量白蛋白参照指标具有较好的敏感性,这为它们在评估糖尿病肾功能的早期损伤中具有了广阔的应用前景和巨大的诊断临床应用价值。
Objective To observe the value of urinary protein and serum cystatin C in diabetic nephropathy. Methods According to the principle of informed consent, 73 cases of diabetic patients and 73 healthy subjects were selected from March 2010 to October 2012 in our hospital to form the observation group and the control group. All patients in the two groups were taken urine test for urine protein, fasting blood and serum cystatin C by latex enhanced immunoturbidimetry, and accurate records, and finally the results were compared. Results Serum cystatin levels (t = 7.8147, P <0.05) and urine microalbumin content (t = 147.2285, P <0.05) were compared between the two groups. The difference was statistically significant (P <0.05). Conclusions Serum cystatin C and urinary microalbumin have good sensitivity, which has broad application prospects and great clinical value in early injury of diabetic nephropathy.