采用胶乳凝集法和间接免疫荧光法 ( IIF)分别测定 97例类风湿性关节炎( RA)患者、1 0 8例非 RA结缔组织病 ( CTD)患者和 65例非 CTD患者的类风湿因子 ( Rf)和抗角蛋血抗体 ( AKA)滴度。结果 :Rf对 RA的敏感性为 87.6% ,特异性为 68.8% ;AKA对RA的敏感性为 5 6.7% ,特异性为 96.5 % ;高滴度的 Rf和 AKA对 RA有更高的特异性。提示 :同时测定 Rf和 AKA对 RA诊断意义明显 The rheumatoid arthritis (RA) patients, rheumatoid arthritis (RA) patients and rheumatoid arthritis patients (n = 108) were enrolled in this study. Rf) and anti-keratinocyte antibody (AKA) titers. Results: The sensitivity and specificity of Rf to RA were 87.6% and 68.8% respectively. The sensitivity and specificity of AKA to RA were 56.7% and 96.5%, respectively. High-titer Rf and AKA had higher specificity for RA . Tip: Simultaneous determination of Rf and AKA on the diagnosis of RA is obvious