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以1，4-环己二酮单乙二醇缩酮和咖啡酸为起始原料，经两条不同的路线完成了（E）-2-（1-羟基-4-环己酮）乙基咖啡酸酯的全合成，并确定了其最佳合成路线，总收率达56％．“,”（＋）-2-（1-Hydroxyl-4-oxocyclohexyl）ethyl caffeate （1）, a new caffeate was first synthesized starting from 1,4-cyclohexanedione monoethyleneketal and caffeic acid through two different routes. The optimum synthetic route was determined, under which the final yield was 56%.