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许多喹啉类抗疟药物具有抗丝虫及血吸虫作用,已知氨酚喹(Ⅰ)、氯喹(Ⅱ)对丝虫微丝蚴有杀灭作用,RD 12869(Ⅲ)对实验小白鼠有抗曼氏血吸虫活性,UK 3883(Ⅳ)用于临床
Many quinoline antimalarial drugs have anti-filarial and Schistosoma japonicum effects. It is known that paracetamol (I) and chloroquine (II) kill filarial microfilariae. RD 12869 (III) is resistant to experimental mice Schistosoma mansoni activity, UK 3883 (IV) for clinical use