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目的 观察低水平(即低氧浓度及低压力)持续气道正压(CPAP)配合纳洛酮治疗早产儿原发性呼吸暂停的疗效。方法将66例患儿随机分为两组,观察组35例给予低水平CPAP及纳洛酮治疗;对照组31例给予氨茶碱治疗。比较两组用药后呼吸暂停改善情况。结果观察组显效24例,有效9例,无效2例,总有效率94.3%,对照组显效12例,有效9例,无效10例,总有效率67.7%,两组之间显效率及总有效率比较,治疗组均明显优于对照组,经统计学处理均有显著性意义(分别为x2=5.91,P<40.025及x2=10.04,P<40.005)。结论 低水平CPAP配合纳洛酮治疗原发性早产儿呼吸暂停,疗效明显优于用氨茶碱治疗
Objective To observe the effect of low level (low oxygen concentration and low pressure) continuous positive airway pressure (CPAP) combined with naloxone on premature infants with primary apnea. Methods Sixty-six children were randomly divided into two groups. 35 cases in the observation group were given low-level CPAP and naloxone, and 31 in the control group were given aminophylline. The improvement of apnea was compared between the two groups after treatment. Results In the observation group, 24 cases were markedly effective, 9 cases were effective, 2 cases were ineffective and the total effective rate was 94.3%. In the control group, 12 cases were markedly effective, 9 effective and 10 ineffective, with a total effective rate of 67.7% Compared with the control group, the treatment group was significantly better than the control group (P <40.025, P <40.025, P <40.025 and P <40.005, respectively). Conclusions Low-level CPAP combined with naloxone in the treatment of apnea in primary premature infants is significantly better than aminophylline