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本文报告用紫外分光光度法监测茶碱血药浓度(C)及唾药浓度(S),采用血清或唾液茶碱回收曲线计算,回收率稳定。测定30例病人口服氨茶碱0.1q8h后稳态茶碱C,峰值<10μg.ml者占90%,测定30例次病人的稳态茶碱C与S,两者相关性非常显著(C=1.53S+1.54,r=0.97,P<0.001),S/C=0.551±0.065(CV11.9%)。本文还分析讨论了口服氨茶碱常规给药方案,认为0.2q8h可对多数病人适用。
This article reports the monitoring of theophylline plasma concentration (C) and salivary drug concentration (S) by UV spectrophotometry. The recoveries were stable with the recovery curve of serum or salivary theophylline. Determination of 30 patients after oral administration of aminophylline 0.1q8h steady theophylline C, peak <10μg.ml accounted for 90%, 30 patients were measured steady-state theophylline C and S, the correlation was very significant (C = 1.53S + 1.54, r = 0.97, P <0.001), S / C = 0.551 ± 0.065 (CV11.9%). This article also analyzes and discusses the conventional oral aminophylline administration program, that 0.2q8h can be applied to most patients.