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Statins are lipid-lowering agents widely used in the treatment of hypercholesterolemia and atherosclerosis. They act by inhibiting of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, an enzyme responsible for the conversion of HMG-CoA to mevalonate in cholesterol biosynthesis. Due to their ability to reduce low-density lipoproteins (LDL) levels more than other cholesterol-lowering drugs, they have become the drugs most often prescribed in the treatment of atherosclerosis.
They act by the regulation of HMG-CoA to mevalonate in cholesterol biosynthesis. Due to their ability to reduce low-density lipoproteins (LDL) levels more than other cholesterol-lowering drugs, they have become the most often prescribed in the treatment of atherosclerosis.