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目的：比较非洛地平缓释片与尼群地平片治疗高血压病的疗效。方法：轻、中度高血压病病人１６２例，其中９８例（男性６７例，女性３１例，年龄５１ａ±ｓ６ａ）用非洛地平缓释片５～１０ｍｇ，ｐｏ，ｑｄ×４ｗｋ治疗。另６４例（男性４７例，女性１７例，年龄５０ａ±８ａ）用尼群地平片１０ｍｇ，ｐｏ，ｂｉｄ或ｔｉｄ×４ｗｋ治疗。结果：非洛地平缓释片组总有效率９５％，与尼群地平片组（８１％）相比，差别有非常显著意义（Ｐ＜０．０１）。不良反应发生率非洛地平缓释片组１５％，与尼群地平片组（２０％）比较，差别有显著意义（Ｐ＜０．０５）。结论：非洛地平缓释片对高血压病的疗效显著而又安全，优于尼群地平片。
Objective: To compare the curative effect of felodipine sustained release tablets and nitrendipine tablets in the treatment of hypertension. Methods: A total of 162 patients with mild and moderate essential hypertension were enrolled. Among them, 98 cases (67 males and 31 females, age 51a ± s6a) were treated with 5 ~ 10mg, po, qd × 4wk of sustained release tablets of felodipine. Another 64 patients (47 males and 17 females, age 50a ± 8a) were treated with nitrendipine 10 mg, po, bid or tid × 4 weeks. Results: The total effective rate of felodipine extended-release tablets was 95%, which was significantly different from that of nitrendipine tablets (81%) (P <0.01). The incidence of adverse reactions was 15% in the non-loidipine extended release tablets group, which was significantly different from that in the nitrendipine tablet group (20%) (P <0.05). Conclusion: Felodipine extended release tablet has obvious and safe curative effect on hypertension, which is superior to nitrendipine tablet.