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目的 :研究三叶委陵菜乙醇提取物的镇痛作用。方法 :热板法和扭体法。结果 :热板法中 ,灌胃三叶委陵菜乙醇提取物 (0 5 g/kg ,1 2 5 g/kg ,2 5g/kg) 15 ,3 0 ,60和 90min后 ,小鼠的痛阈均明显延长 ,其中灌胃 2 5g/kg提取物 90min后的镇痛效应比氨基比林 (10 0mg/kgi.m .)的好。在对非甾体药敏感的扭体法中 ,不同剂量的三叶委陵菜醇提物 (0 5 g/kg ,1 2 5 g/kg ,2 5 g/kgo .p .)均能显著抑制 0 7%醋酸引起的扭体反应。 结论 :三叶委陵菜具有镇痛效应 ,民间用三叶委陵菜医治牙痛及其它疼痛症的疗效得到了验证。
Objective : To study the analgesic effect of ethanol extract from Potentilla trifoliata. Methods: Hot plate method and writhing method. RESULTS: In the hot plate method, mice were pained after intragastric administration of ethanol extracts of Potentilla trifoliata (0 5 g/kg, 152 g/kg, 25 g/kg) for 15, 30, 60 and 90 min. The thresholds were significantly prolonged, and the analgesic effect of gavage at 25 g/kg extract for 90 min was better than that of aminopyrine (100 mg/kg i.m.). In the writhing method sensitive to non-steroidal drugs, different doses of ethanol extracts of P. trifoliata (0 5 g/kg, 1.25 g/kg, 25 g/kg.p.) were significant. Inhibition of 0.7% acetic acid induced writhing. Conclusion :Three-leaf Potentilla has analgesic effect, and the curative effect of folk trilingual poetics in treating toothache and other pain is verified.