This paper firstly investigated the land-use and land-cover change (LUCC) in the Hun-Taizi River watershed, Northeast China from 1988 to 2004 based on remotely sensed images and geographic information systems (GIS) technology. Then, using the famous land-use change model of Conversion of Land Use and its Effects at Small regional extent (CLUE-S), this paper simulated the land use changes under historical trend (HT), urban planning (UP) and ecological protection (EP) scenarios considering urban planning and ecological protection over the next 20 years. The simulated results under UP scenario in 2020 were compared with the planning map to assess the feasibility of using land-use change model to guide regional planning. Results show that forest land, dry farmland, paddy, and shrub land were the main land-use categories. Paddy and dry farmland being converted to urban area and rural settlement characterized the land-use change from 1988 to 2004. The main land-use categories changed over time. Landscape-pattern fragmentation will be worse under HT and UP scenarios, but better in EP scenario. The comparing results of simulated map with planning map in 2020 show that land-use change model is powerful tool to guide regional planning. Land-use scenarios can support regional planning and policy-making through analyzing future consequences scientifically. This paper first examined the land-use and land-cover change (LUCC) in the Hun-Taizi River watershed, Northeast China from 1988 to 2004 based on remotely sensed images and geographic information systems (GIS) technology. -use change model of Conversion of Land Use and its Effects at Small regional extent (CLUE-S), this paper simulated the land use changes under historical trend (HT), urban planning (UP) and ecological protection planning and ecological protection over the next 20 years. The simulated results under UP scenario in 2020 were compared with the planning map to assess the feasibility of using land-use change model to guide regional planning. Results show that forest land, dry farmland, paddy , and shrub land were the main land-use categories. Paddy and dry farmland being converted to urban area and rural settlement characterized land-use change from 1988 to 2004. The main land-use categories changed over ti me. Landscape-pattern fragmentation will be worse under HT and UP scenarios, but better in EP scenario. The comparing results of simulated map with planning map in 2020 show that land-use change model is powerful tool to guide regional planning. Land-use scenarios can support regional planning and policy-making through analyzing future consequences scientifically.