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【摘要】目的:探讨阿奇霉素序贯疗法联合孟鲁司特钠治疗小儿支原体肺炎的临床分析。方法:选取2018年11月至2020年6月的医院临床治疗的患有小儿支原体肺炎的患者50例作为研究对象,随机分成观察组(n=25例)和对照组(n=25例),对照组采用单纯阿奇霉素进行治疗,观察组采用阿奇霉素序贯疗法联合孟鲁司特钠进行治疗;治疗后,对患者的治疗效果进行有效评估,比较两组患者的临床相关指标变化以及治疗后的总有效率。结果:治疗后,观察组患者肺部啰音消失时间、咳嗽消失时间,住院时间以及退热时间均低于对照组(P<0.05),治疗后,观察组患者的总有效率高于对照组(P<0.05)。结论:临床上使用阿奇霉素序贯疗法联合孟鲁司特钠治疗小儿支原体肺炎,能够有效缓解患者的肺部啰音以及咳嗽症状,降低退热时间以及住院时间,提高患者生活质量,能够有效提高患者临床治疗效果,有利于患者恢复。
【关键词】阿奇霉素序贯疗法;孟鲁司特钠;小儿支原体肺炎
[中图分类号]R725.6 [文献标识码]A [文章编号]2096-5249(2021)09-0069-02
Clinical analysis of Azithromycin Sequential Therapy Combined with montelukast sodium in the treatment of mycoplasma pneumonia in children
LI Jun (Department of Pediatrics, Dongtai people’s Hospital, Dongtai Jiangsu 224200, China)
[Abstract] Objective: To explore the clinical analysis of Azithromycin Sequential Therapy Combined with montelukast sodium in the treatment of mycoplasma pneumonia in children. Methods: from November 2018 to June 2020, 50 patients with mycoplasma pneumonia in children were randomly divided into observation group (n=25) and control group (n=25). The control group was treated with azithromycin alone, and the observation group was treated with Azithromycin Sequential Therapy Combined with montelukast sodium; After treatment, the treatment effect of patients was effectively evaluated, and the changes of clinical related indicators and the total effective rate of the two groups were compared. Results: after treatment, the disappearance time of pulmonary rales, cough, hospitalization time and antipyretic time of the observation group were lower than those of the control group (P<0.05), and the total effective rate of the observation group was higher than that of the control group (P<0.05). Conclusion: the clinical use of Azithromycin Sequential Therapy Combined with montelukast sodium in the treatment of children with mycoplasma pneumonia can effectively alleviate the lung rales and cough symptoms of patients, reduce the fever time and hospitalization time, improve the quality of life of patients, can effectively improve the clinical treatment effect of patients, and is conducive to the recovery of patients.
[Key words] Azithromycin Sequential Therapy; Montelukast sodium; Mycoplasma pneumonia in children
由于处于生长发育期的儿童的肺部纤毛运动能力不强,所以,很容易受到病原微生物的感染,加之儿童的自身免疫功能不强,以肺炎为主的肺部感染性疾病,成为了儿童的常见病和多发病。支原体肺炎是小儿肺炎中的一种,在儿童中的发病率非常高,必须采取及早有效的治疗,如果治疗不及时,病情会快速加剧,病原体会侵袭小儿的脏器,导致器官病变,严重威胁儿童的身体健康。支原体肺炎主要是由于患者体内的支原体肺炎进行诱导,用于改变肺间质性质而产生的肺炎[1]。肺炎支原体是处于病毒与细菌之间的一种病原体,该类物质不含细胞壁,含有细胞膜,能够独立生存,可以通过飞沫或者是呼吸道进行,传播速度极快。支原体肺炎临床表现为发热,咳嗽,呼吸困难等,同时体温保持在39℃左右。由于目前抗生素药物的普遍使用,导致细菌性肺炎发生效率较低,因此支原体肺炎呈现上升趋势。该类肺炎主要是由支原体感染引起,肺泡中会携带少量的炎癥渗出物质,会造成患者肺不张症状[2]。儿童的抵抗能力以及自身免疫功能较差,成为该类病症的主要传染人群,同时该类症状若早期未进行及时治疗,病情发展会导致患者出现心血管疾病。但是,阿奇霉素序贯疗法联合孟鲁司特钠治疗小儿支原体肺炎的临床研究较少,因此,本研究以小儿支原体肺炎患者作为对象,探讨阿奇霉素序贯疗法联合孟鲁司特钠治疗小儿支原体肺炎的临床疗效,报道如下。
【关键词】阿奇霉素序贯疗法;孟鲁司特钠;小儿支原体肺炎
[中图分类号]R725.6 [文献标识码]A [文章编号]2096-5249(2021)09-0069-02
Clinical analysis of Azithromycin Sequential Therapy Combined with montelukast sodium in the treatment of mycoplasma pneumonia in children
LI Jun (Department of Pediatrics, Dongtai people’s Hospital, Dongtai Jiangsu 224200, China)
[Abstract] Objective: To explore the clinical analysis of Azithromycin Sequential Therapy Combined with montelukast sodium in the treatment of mycoplasma pneumonia in children. Methods: from November 2018 to June 2020, 50 patients with mycoplasma pneumonia in children were randomly divided into observation group (n=25) and control group (n=25). The control group was treated with azithromycin alone, and the observation group was treated with Azithromycin Sequential Therapy Combined with montelukast sodium; After treatment, the treatment effect of patients was effectively evaluated, and the changes of clinical related indicators and the total effective rate of the two groups were compared. Results: after treatment, the disappearance time of pulmonary rales, cough, hospitalization time and antipyretic time of the observation group were lower than those of the control group (P<0.05), and the total effective rate of the observation group was higher than that of the control group (P<0.05). Conclusion: the clinical use of Azithromycin Sequential Therapy Combined with montelukast sodium in the treatment of children with mycoplasma pneumonia can effectively alleviate the lung rales and cough symptoms of patients, reduce the fever time and hospitalization time, improve the quality of life of patients, can effectively improve the clinical treatment effect of patients, and is conducive to the recovery of patients.
[Key words] Azithromycin Sequential Therapy; Montelukast sodium; Mycoplasma pneumonia in children
由于处于生长发育期的儿童的肺部纤毛运动能力不强,所以,很容易受到病原微生物的感染,加之儿童的自身免疫功能不强,以肺炎为主的肺部感染性疾病,成为了儿童的常见病和多发病。支原体肺炎是小儿肺炎中的一种,在儿童中的发病率非常高,必须采取及早有效的治疗,如果治疗不及时,病情会快速加剧,病原体会侵袭小儿的脏器,导致器官病变,严重威胁儿童的身体健康。支原体肺炎主要是由于患者体内的支原体肺炎进行诱导,用于改变肺间质性质而产生的肺炎[1]。肺炎支原体是处于病毒与细菌之间的一种病原体,该类物质不含细胞壁,含有细胞膜,能够独立生存,可以通过飞沫或者是呼吸道进行,传播速度极快。支原体肺炎临床表现为发热,咳嗽,呼吸困难等,同时体温保持在39℃左右。由于目前抗生素药物的普遍使用,导致细菌性肺炎发生效率较低,因此支原体肺炎呈现上升趋势。该类肺炎主要是由支原体感染引起,肺泡中会携带少量的炎癥渗出物质,会造成患者肺不张症状[2]。儿童的抵抗能力以及自身免疫功能较差,成为该类病症的主要传染人群,同时该类症状若早期未进行及时治疗,病情发展会导致患者出现心血管疾病。但是,阿奇霉素序贯疗法联合孟鲁司特钠治疗小儿支原体肺炎的临床研究较少,因此,本研究以小儿支原体肺炎患者作为对象,探讨阿奇霉素序贯疗法联合孟鲁司特钠治疗小儿支原体肺炎的临床疗效,报道如下。