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目的探析老年性骨质疏松合并高脂血症患者用阿仑膦酸钠、辛伐他汀联合治疗方案的临床效果。方法纳入研究对象为2014年6月至2016年12月期间本院诊治的60例老年性骨质疏松伴高脂血症患者的临床资料,编序后以随机数字表法将其以每组30例分为单药组(单纯用阿仑膦酸钠治疗)和联合组(联合辛伐他汀治疗)。在疗程后比较两者的临床应用效果差异。结果治疗后,联合组患者临床疗效显著优于单一组(P<0.05);联合组患者血脂指标改善显著优于单一组(P<0.05);联合组患者不良反应率显著低于单一组(P<0.05)。结论对合并高脂血症的老年性骨质疏松患者制定治疗方案时,可将阿仑膦酸钠联合辛伐他汀药物作为主要干预措施,效果突出且安全性高。
Objective To investigate the clinical effects of combined treatment with alendronate and simvastatin in senile osteoporosis patients with hyperlipidemia. Methods The clinical data of 60 elderly patients with osteoporosis and hyperlipidemia treated in our hospital from June 2014 to December 2016 were included in the study. After randomization, Cases were divided into monotherapy group (simple treatment with alendronate) and the combination group (combined with simvastatin treatment). After treatment, the difference between the two clinical effects. Results After treatment, the clinical efficacy of the combination group was significantly better than that of the single group (P <0.05). The improvement of serum lipids in the combined group was significantly better than that of the single group (P <0.05). The adverse reaction rate in the combination group was significantly lower than that in the single group <0.05). Conclusions In the treatment of senile osteoporosis patients with hyperlipidemia, alendronate and simvastatin can be used as the main intervention in the treatment of senile osteoporosis patients with high efficacy and safety.