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目的 :评估山莨菪碱对急性分泌性中耳炎的辅助治疗作用。方法 :将 6 1例确诊为急性分泌性中耳炎患者随机分为两组 :对照组 30例 ,给予 1%新麻液 (新霉素加麻黄素 )滴鼻 ,口服开瑞坦 10mg/次 ,1次 /d ;西力欣 2 5 0mg/次 ,3次 /d。山莨菪碱组 31例 ,一般治疗同对照组 ,加服山莨菪碱 ,10mg/次 ,2次 /d。在治疗 5、10d时 ,比较两组治疗效果。结果 :治疗 5d时 ,山莨菪碱组患者听力改善率、耳鸣消失率、鼓室积液吸收率及咽鼓管功能曲线正常率明显高于对照组 (P <0 .0 5或P <0 .0 1) ;治疗 10d时 ,患者听力改善率、耳鸣消失率和鼓室积液吸收率 ,两组差异无统计学意义 (P >0 .0 5 ) ,但山莨菪碱组咽鼓管功能曲线正常率明显高于对照组 (P <0 .0 1)。结论 :山莨菪碱通过改善咽鼓管功能和内耳微循环辅助治疗急性分泌性中耳炎具有较好的临床疗效
Objective: To evaluate the adjuvant therapy of anisodamine on acute otitis media with effusion. Methods: Sixty-one patients with acute otitis media with effusion were randomly divided into two groups: control group (n = 30), intranasal administration of 1% neomycin (neomycin plus ephedrine) / d; Xili Xin 250mg / time, 3 times / d. Anisodamine group of 31 cases, the general treatment with the control group, plus anisodamine, 10mg / time, 2 times / d. At 5 and 10 days of treatment, the treatment effect was compared between the two groups. Results: After 5 days of treatment, the improvement rate of hearing, the disappearance of tinnitus, the absorption rate of tympanic fluid and the normal rate of Eustachian tube function curve were significantly higher in the anisodamine group than those in the control group (P <0.05 or P <0. 0 1) .There was no significant difference between the two groups in hearing improvement rate, tinnitus disappearance rate and tympanic effusion absorption rate at 10 days (P> 0.05), but the normal rate of Eustachian tube function curve in anisodamine group Significantly higher than the control group (P <0.01). Conclusion: Anisodamine has better clinical efficacy by improving eustachian tube function and inner ear microcirculation in adjuvant treatment of acute otitis media with effusion