急性心肌梗塞(AMI)患者大约10%在出院后1年内死亡,β阻滞剂能使此期死亡危险下降25%,但仅25%～50%病例适宜采用β阻滞剂治疗。AMI 后1年内死亡危险主要是心律失常,已证明Ⅰ类抗心律失常药不能降低病死率,其中有些(如恩卡胺和氟卡胺)甚至增加死亡危险。因此,对那些不适宜采用β阻滞剂治疗的AMI 患者,尚未找到能有效降低猝死危险的疗法。研究对象为613例不适宜采用β阻滞剂治 Approximately 10% of patients with acute myocardial infarction (AMI) die within 1 year of discharge and beta blockers reduce the risk of death by 25% in this period, but only 25% to 50% of patients are eligible for beta blocker therapy. The major risk of death within 1 year after AMI is arrhythmia. Class I antiarrhythmic drugs have been shown not to reduce mortality, and some of them (such as enkaamine and flecainide) may even increase the risk of death. Therefore, for those patients with AMI who are not suitable for treatment with beta-blocker, no effective therapy has been found to reduce the risk of sudden death. Study of 613 cases is not suitable for treatment with β blockers