采用免疫组化SP法,对细胞粘附分子CD15和人类主要组织相容性复合体HLA—DR抗原在慢性肝炎中的表达情况进行了研究。结果发现慢迁肝和慢活肝中,枯否氏细胞、浸润淋巴细胞和单核细胞呈CD15阳性染色,而肝细胞和肝窦内皮细胞均为阴性反应;肝窦内皮细胞、枯否氏细胞和浸润单核细胞呈HLA-DR阳性染色。其中1例少部分肝细胞膜上有HLA-DR抗原的表达。结果提示CD15和HLA—DR参与了慢性肝损害的过程。 Immunohistochemical SP method was used to study the expression of CD15 and HLA-DR, a major human histocompatibility complex, in chronic hepatitis. The results showed that the slow-moving liver and slow-living liver, Kupffer cells, infiltrating lymphocytes and monocytes were CD15-positive staining, and liver cells and sinusoidal endothelial cells were negative; sinusoidal endothelial cells, Kupffer cells And infiltrating monocytes showed HLA-DR positive staining. One case of a small part of the liver cell membrane HLA-DR antigen expression. The results suggest that CD15 and HLA-DR are involved in the process of chronic liver damage.