在肝病患者中,脑病可能既有“肝门系统”的又有“非肝门系统”两种病因.肝病学者们已提出关于前者病因的概念.即:因为自发性肝门系统侧枝循环或极差的肝脏机能,肠衍生的毒素进入体循环并导致特有的大脑紊乱.这些毒素多来自细菌代谢产物.人们已广泛地对氨进行了研究,并提出了氨对各种脑毒性机制的解释,包括妨碍克雷布斯循环和抑制性神经递质r-氨基丁酸的积累,然而支 In patients with liver disease, encephalopathy may have both the “liver door system” and “non-hepatic system.” Liver disease scholars have put forward the concept of the former cause that: Because of the spontaneous hepatic portal system Collateral circulation or poor liver function, intestinal-derived toxins enter the systemic circulation and lead to specific brain disorders, most of which come from bacterial metabolites.Ammonia has been studied extensively and ammonia is proposed for various brain mechanisms of toxicity , Including interfering with the Krebs cycle and the accumulation of the inhibitory neurotransmitter r-aminobutyric acid, however