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目的 观察白介素 2 (IL 2 )加干扰素 α(IFN α)体外净化完全缓解后的急性白血病骨髓 (BM)进行骨髓移植 (ABMT)的临床疗效。方法 用IL 2加IFN α体外净化ABMT患者的BM ,培养 3天后回输给患者。结果 4例患者输用净化处理的BM后均成功恢复造血功能 ,3例患者移植后至今分别持续缓解超过 2 7,2 8,30个月 ;其中 1例急性淋巴细胞白血病患者移植前染色体为Ph(+) ,移植后 2个月Ph染色体转阴 ;1例患者于移植后 3个月复发 ,3个月惑死亡。结论 初步研究显示 ,IL 2加IFN α用于临床移植患者是安全可行的 ,并且对白血病患者的骨髓有一定的净化作用
Objective To observe the clinical efficacy of bone marrow transplantation (ABMT) in the treatment of acute leukemia (BM) with complete remission of interleukin 2 (IL 2) and interferon α (IFN α) in vitro. Methods The BMs of ABMT patients were purified with IL-2 and IFN-α in vitro. After three days of culture, they were transfused to the patients. Results All the 4 patients successfully recovered the hematopoietic function after being treated with decontamination BM, and the three patients continued to relieve more than 27, 28 and 30 months respectively after transplantation. Among them, one patient with acute lymphoblastic leukemia had Ph chromosome (+). Ph chromosome was negative at 2 months after transplantation. One patient recurred 3 months after transplantation and died at 3 months. Conclusion Preliminary studies have shown that IL 2 plus IFN α is safe and feasible for clinical transplant patients and has some purifying effect on bone marrow of leukemia patients