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平均61(22～90)岁的626(男494、女132)例冠心病患者进行650次大剂量多巴酚丁胺-阿托品负荷超声心动图试验,其中300例有心梗史。负荷试验期间心率从73bpm增至129bpm,血压未显著改变(从140/81 mmHg至150/80mmHg)。239例单用多巴酚丁胺和达到预期最大心率的85％,未能诱发心肌缺血,加用阿托品。使用β阻滞剂者比不用β阻滞剂者较多加用阿托品(77％对27％,P<0.001)。243例(37％)新出现室室活动异常。24次试验中出现明显的或有症状的快速心律
Sixty-two high-dose dobutamine-atropine stress echocardiography tests were performed on 626 (494, 132) women with coronary heart disease 61 (22-90) years of age, of whom 300 had a history of myocardial infarction. Heart rate increased from 73bpm to 129bpm during the stress test, and blood pressure did not change significantly (from 140/81 mmHg to 150/80 mmHg). 239 cases of dobutamine alone and 85% of the expected maximum heart rate, failed to induce myocardial ischemia, plus atropine. Atropine (77% vs. 27%, p <0.001) was more commonly administered with beta blockers than without beta blockers. 243 cases (37%) new abnormal ventricular activity. Twenty-four trials showed significant or symptomatic tachyarrhythmias