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目的:观察加味补阳还五汤联合常规西医疗法治疗急性脑梗死的临床效果。方法:选取226例急性脑梗死气虚血瘀证患者,随机分为2组各113例,治疗组采用常规西医疗法结合加味补阳还五汤治疗,对照组以常规西医疗法治疗。2组患者均治疗2周。观察2组患者的临床症状改善情况,比较治疗前后2组患者的血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)含量和美国国立卫生研究院卒中量表(NIHSS)评分。结果:治疗后,治疗组总有效率为93.8%,对照组总有效率为80.5%,2组比较,差异有统计学意义(P<0.01)。2组血清TNF-α、IL-6、hs-CRP和NIHSS评分均较治疗前有不同程度的下降(P<0.01,P<0.05),治疗组各项指标值均低于对照组(P<0.05)。结论:加味补阳还五汤联合常规西医疗法治疗急性脑梗死气虚血瘀证患者,可明显缓解临床症状、改善神经功能,降低炎症反应,提高治疗效果。
Objective: To observe the clinical effects of Jiawe BuYuanHuWu Decoction combined with conventional western medicine in the treatment of acute cerebral infarction. Methods: A total of 226 patients with acute cerebral infarction with deficiency of qi and blood stasis were selected and randomly divided into two groups (n = 113). The patients in the treatment group were treated with western medicine plus Jia Yang Bu Yang Huan Wu Tang and the control group with conventional western medicine. Two groups of patients were treated for 2 weeks. The clinical symptoms of the two groups were observed. The levels of serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and hs-CRP ) Content and the National Institutes of Health Stroke Scale (NIHSS) score. Results: After treatment, the total effective rate was 93.8% in the treatment group and 80.5% in the control group. There was significant difference between the two groups (P <0.01). The levels of TNF-α, IL-6, hs-CRP and NIHSS in the two groups were decreased to some extent before treatment (P <0.01, P <0.05), and the indexes in the treatment group were all lower than those in the control group (P < 0.05). Conclusion: Jiaweibuhuanyuan Decoction combined with routine Western medical treatment of patients with acute cerebral infarction with deficiency of qi and blood stasis can relieve clinical symptoms, improve neurological function, reduce the inflammatory reaction and improve the therapeutic effect.