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骨是恶性肿瘤最常见的转移部位之一。白细胞介素-6(Interleukin-6,IL-6)作为一种多功能细胞因子,除了作用于成骨细胞和破骨细胞调控骨代谢外,在骨微环境中以自分泌和旁分泌作用方式通过激活胞内多种信号转导途径促进肿瘤细胞增殖和生长,同时增强肿瘤细胞的多药耐受。IL-6可能作为一个重要的肿瘤治疗靶点在肿瘤治疗中发挥重要作用。
Bone is one of the most common metastatic sites of malignancy. As a multifunctional cytokine, Interleukin-6 (IL-6), besides acting on osteoblasts and osteoclasts to regulate bone metabolism, acts in an autocrine and paracrine manner in the bone microenvironment By activating a variety of intracellular signaling pathways to promote tumor cell proliferation and growth, while enhancing tumor cell multidrug resistance. IL-6 may play an important role in cancer therapy as an important tumor therapeutic target.