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将60例初发肥胖2型糖尿病患者随机分为治疗组、对照组,每组30例。二组都给予以胰岛素+二甲双胍的基础治疗,治疗组在基础治疗上给予以黄连素0.2一日三次的综合治疗,疗程3个月。比较患者治疗前后血糖控制情况、胰岛素抵抗指数(HOMA-IR)、超敏CRP(hs CRP)、肿瘤坏死因子(TNF-α)、白介素6(IL-6)。结果治疗组与对照组血糖控制、胰岛素抵抗指数(HOMA-IR)、超敏CRP(hs CRP)、肿瘤坏死因子(TNF-α)、白介素6(IL-6)较治疗前均有明显下降,治疗组较对照组下降更为明显(P<0.05)。结论中西医结合综合治疗初发肥胖2型糖尿病能显著控制患者的血糖水平,其机制可能与降低炎症因子水平后减轻胰岛素抵抗有关。
Sixty patients with newly diagnosed obese type 2 diabetes were randomly divided into treatment group and control group, 30 cases in each group. Two groups were given insulin + metformin basic treatment, the treatment group was given basic treatment of berberine 0.2 three times a day of comprehensive treatment, course of treatment of 3 months. The blood glucose control, insulin resistance index (HOMA-IR), hs CRP, TNF-α and IL-6 in patients before and after treatment were compared. Results The blood glucose control, HOMA-IR, hsCRP, TNF-α and IL-6 in treatment group and control group were significantly lower than those before treatment, The treatment group decreased more significantly than the control group (P <0.05). Conclusion Integrated Chinese and Western medicine treatment of newly diagnosed obese type 2 diabetes can significantly control the blood glucose levels in patients with the mechanism may be related to reducing the level of inflammatory cytokines and reduce insulin resistance.