阿霉素是蒽环类广谱抗肿瘤的抗生素,单独应用对数种恶性肿瘤可获良好效果,客观有效率约在20～40％的范围。目前已用于治疗肉瘤、乳腺癌、肺癌、淋巴瘤、神经母细胞瘤、急性白血病、睾丸癌和膀胱癌。阿霉素常用剂量为60mg/M~2,静脉注射,每3或4周一次,合用其他药物时剂量可减少。单次用量超过60mg/M~2并不增加疗效,但在60mg/M~2内其疗效则与剂量相关。阿霉素静脉注射后,很快在组织内分布,但不能通过血脑屏障。该药由肝代谢,胆汁排泄。原有肝功能不良的病人应用后,阿霉素及其代谢产物在血浆中的浓度会明显延长,因而会加重临床的毒性反应,甚至非常严重。所 Doxorubicin is an anthracycline-based broad-spectrum anti-tumor antibiotic. Good anti-tumor efficacy can be achieved by using several types of malignant tumors alone. The objective and effective rate is about 20 to 40%. It has been used to treat sarcoma, breast cancer, lung cancer, lymphoma, neuroblastoma, acute leukemia, testicular cancer and bladder cancer. Doxorubicin commonly used dose is 60mg/M ~ 2, intravenous injections, once every 3 or 4 weeks, combined with other drugs can reduce the dose. Single dose of more than 60mg/M~2 does not increase the therapeutic effect, but its efficacy is dose-related within 60mg/M~2. After intravenous injection of adriamycin, it is distributed within the tissue but cannot pass through the blood-brain barrier. The drug is metabolized by the liver and excreted in the bile. After the application of the original liver dysfunction patients, the concentration of adriamycin and its metabolites in the plasma will be significantly prolonged, which will increase the clinical toxicity, even very serious. By