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检测了４７例胃溃疡和溃疡型胃癌老年病人的细胞毒因子（ＭＣＣＦ）、肿瘤坏死因子（ＴＮＦ）活性和淋巴细胞转化（淋转）功能的变化。结果上述病人的外周血单个核细胞（ＰＢＭＣｓ）产生ＭＣＣＦ活性和淋转均有不同程度的降低，以胃癌病人的改变更为明显。提示机体抗肿瘤的免疫活性低下，可能为胃肿瘤的发生或老年人胃溃疡恶变的原因之一。胃癌已转移患者的血清ＴＮＦ活性低于无转移者，动态观察ＴＮＦ活性变化与其肿瘤术后复发和预后不良有关。检测血清ＴＮＦ活性可做为观察胃癌疗效和判断预后的指标。
The changes of cytotoxicity factor (MCCF), tumor necrosis factor (TNF) activity, and lymphocyte transformation (lipid transfer) function were examined in 47 elderly patients with gastric ulcer and ulcerated gastric cancer. Results The peripheral blood mononuclear cells (PBMCs) produced by these patients showed decreased levels of MCCF activity and lymphocytosis. The changes in patients with gastric cancer were even more pronounced. It suggests that the body’s anti-tumor immune activity is low, which may be one of the causes of stomach cancer or malignant transformation of gastric ulcer in the elderly. The activity of serum TNF in patients with metastatic gastric cancer was lower than those without metastasis. Dynamic observation of TNF activity was associated with postoperative recurrence and poor prognosis. Detection of serum TNF activity can be used as an indicator to observe the efficacy of gastric cancer and determine its prognosis.