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Graves病者治疗前常有血清三碘甲状腺原氨酸(T_3)/甲状腺素(T_4)比值增高。适当抗甲状腺药治疗后血T_3及T_4水平可望恢复正常。然而有些患者经治后T_3仍持续增高而T_4正常,T_3/T_4>20,这种类型称之为T_3优势的Graves病。本研究旨在说明此类患者是否应增加抗甲状腺药物的剂量或改换药物以及T_3过多的机制等问题。方法Graves病167例,治疗前血清T_3、T_4均高,研究开始时用丙基硫氧嘧啶每天300mg和他巴唑每天30mg,以后剂量调整使血清T_4和TSH维
Graves patients often before treatment serum triiodothyronine (T_3) / thyroid hormone (T_4) ratio increased. Appropriate anti-thyroid drug treatment of blood T_3 and T_4 levels are expected to return to normal. However, some patients continued to increase after treatment T_3 and T_4 normal, T_3 / T_4> 20, this type is called T_3 dominant Graves disease. The aim of this study is to show whether such patients should increase the dosage of anti-thyroid drugs or change drugs and the mechanism of excessive T_3. Methods 167 cases of Graves disease, serum T_3, T_4 before treatment were high, the study started with propylthiouracil 300mg daily and methimazole 30mg, after dose adjustment to serum T_4 and TSH dimension