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目的研究经皮给药治疗婴儿迁延性腹泻的疗效。方法把200例婴儿符合迁延性腹泻病诊断标准的患儿,随机分为两组,治疗组100例,对照组100例,两组均给予口服蒙脱石散,微生态制剂,低钙者加服钙剂等常规治疗,治疗组在常规治疗的基础上,加用经皮给药,比较两组用药后的总有效率。结果治疗组总有效率96.00%;对照组总有效率84.00%,两组总有效率比较有统计学意义(P<0.01)。结论经皮给药治疗婴儿迁延性腹泻疗效肯定,经皮给药无不良反应,且使用方便,儿童依从性好,可以在临床上推广应用。
Objective To study the efficacy of transdermal delivery in the treatment of persistent diarrhea in infants. Methods 200 infants with diagnostic criteria for persistent diarrhea in children were randomly divided into two groups, the treatment group of 100 patients and the control group of 100 patients, both groups were given oral montmorillonite powder, probiotics, low calcium plus Calcium and other conventional services, the treatment group on the basis of conventional treatment, plus the use of transdermal delivery, the total efficiency of the two groups after treatment compared. Results The total effective rate of the treatment group was 96.00%; the total effective rate of the control group was 84.00%. The total effective rate of the two groups was statistically significant (P <0.01). Conclusion Transdermal drug delivery is effective in treating persistent diarrhea in infants and has no adverse reactions after transdermal administration. It is easy to use and has good compliance. It can be widely applied in clinic.