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应用粘液组化方法对二甲肼(1,2-dimethylhydrazine,DMH)诱发大鼠大肠癌过程的粘液分泌进行了研究。结果显示40只实验大鼠,经DMH注射后,大肠粘膜呈现不同程度的病变及粘液分泌改变。增生区粘膜主要分泌硫酸粘液,与20只对照大鼠大肠粘液分泌相似;不典型增生粘膜和腺瘤随异型度增加,粘液分泌量减少,呈唾液酸粘液为主;大肠癌多数无粘液分泌或呈唾液酸硫酸混合粘液。提示大肠粘膜或腺瘤不典型增生的唾液酸粘液增多或粘液分泌缺乏可能代表其恶性倾向,亦证实大肠癌的发生系经腺瘤癌变或扁平粘膜不典型增生直接发生。
The mucous secretion induced by 1,2-dimethylhydrazine (DMH) in rats was studied by mucus histochemical method. The results showed that in 40 experimental rats, after DMH injection, the mucous membranes of the large intestine showed changes in lesions and mucus secretion. The mucous membrane of the proliferative area mainly secreted mucin sulfate, which was similar to the secretion of mucous in the large intestine of 20 control rats; the mucosal and adenomas of atypical hyperplasia increased with the heterotypic degree, and the secretion of mucus decreased, showing mainly sialic acid mucus; most of the colon cancer had no mucus secretion or Sialic sulfuric acid mixed mucus. The increased sialic acid mucus or lack of mucus secretion in the atypical hyperplasia of the large intestine mucosa or adenoma may represent a malignant tendency, and it is also confirmed that the occurrence of colorectal cancer occurs directly through adenoma canceration or dysplasia of the flat mucous membrane.