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儿茶酚胺持续静脉滴注(静滴)于用治疗心力衰竭虽收到疗效,但当减量或停用时病情恶化,呈现为难治性心力衰竭。对这类难以撤掉静滴给药的患者正在研制口服用的正性肌力药物。左旋多巴(L-dopa)用于震颤麻痹的治疗时,此药通过血脑屏障入脑,经脑内脱羧酶转变为多巴胺。因为吡多醇(维生素 B_6)是脱羧酶的辅酶,同时应用此两种药物时,脑外的脱羧酶活性增加,L-dopa 在到脑之前即可代谢为多巴胺,这样可以减少其
Catecholamine continuous intravenous infusion (intravenous infusion) in the treatment of heart failure, although the received effect, but when reduced or discontinued when the disease deteriorated, showing refractory heart failure. In patients with intravenous infusion of these is difficult to remove intravenous inotropic agents. When L-dopa is used in the treatment of Parkinson’s, it passes through the blood-brain barrier into the brain and is converted to dopamine by decarboxylase in the brain. Because pyridoxine (vitamin B_6) is a decarboxylase coenzyme, at the same time the application of these two drugs, extracellular decarboxylase activity increased, L-dopa can be metabolized to dopamine before the brain, which can reduce its