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目的研究早期糖尿病肾病患者采取丹红注射液联合缬沙坦对患者血清胱抑素C(Cys-C)及β2微球蛋白(β2-MG)水平的影响,为临床提供有力的依据。方法 100例早期糖尿病肾病患者依照入院先后分为对照组与研究组,各50例。两组患者全部接受口服降糖药物、常规糖尿病饮食等控制血糖,对照组患者接受缬沙坦治疗,研究组患者在缬沙坦治疗基础之上加用丹红注射液,两组患者持续治疗2周,比较两组患者血清Cys-C及β2-MG水平。结果两组治疗前血清Cys-C及β2-MG水平比较差异无统计学意义(P>0.05);治疗后,研究组血清Cys-C及β2-MG水平[(0.9±0.2)mg/L、(1.8±0.1)mg/L]显著低于对照组[(1.6±0.2)mg/L、(2.7±0.2)mg/L],差异具有统计学意义(P<0.05)。结论针对早期糖尿病肾病患者采取丹红注射液联合缬沙坦治疗,能够明显降低血清Cys-C及β2-MG水平,有助于改善肾小球滤过情况,保护肾脏,值得在临床中大力推广使用。
Objective To study the effect of Danhong injection combined with valsartan on the serum levels of cystatin C (Cys-C) and β2-microglobulin (β2-MG) in patients with early diabetic nephropathy and provide a strong evidence for clinical practice. Methods 100 patients with early diabetic nephropathy were divided into control group and study group according to admission, each 50 cases. The two groups of patients all received oral glucose-lowering drugs, conventional diabetes diet and other control of blood sugar, patients in the control group received valsartan treatment, patients in the study group on the basis of valsartan plus Danhong injection, two groups of patients continued treatment 2 Weeks, serum Cys-C and β2-MG levels were compared between the two groups. Results There was no significant difference in serum Cys-C and β2-MG levels between the two groups before treatment (P> 0.05). After treatment, serum levels of Cys-C and β2-MG in the study group were (0.9 ± 0.2) mg / (1.8 ± 0.1) mg / L] was significantly lower than that of the control group [(1.6 ± 0.2) mg / L and (2.7 ± 0.2) mg / L], respectively, with statistical significance (P <0.05). Conclusion Danhong injection combined with valsartan can reduce the levels of serum Cys-C and β2-MG in patients with early diabetic nephropathy, which may help to improve glomerular filtration and protect the kidneys. It is worth to be promoted clinically use.