Objectives Over-hydration in diabetic ketoacidosis(DKA) may increase the risk of cerebral edema in children.Methods We have organized a prospective descriptive cohort study of 38pediatric patients aged 1month to 14years,who were diagnosed with DKA with 41episodes of diabetic ketoacidosis,presented to the pediatric emergency department at the First Affiliated Hospital of Xinjiang Medical University from January 2010to February 2012.This study was approved by the Ethics Committee of The First Affiliated Hospital of Xinjiang Medical University.Results The magnitude presentation of the percentile 25%-70% was in the ratio of 5.6%(3.4%-8.2%)(6.1±4).So there was no clinical and biochemical assessment variation needed.These both of the variations,all of the diabetic ketoacidosis patient approached.Further all the patient variations were not correlated with the amplitude of variation and magnitude presentation and did not affect the fluid concentration and the quantity of the fluid was 47.8mL / kg(36.556.3) in the first 12hours.Conclusion For the conclusion of the exact parameters and the magnitude variations of the fluid in the patients of diabetic ketoacidosis,all of the conformations need study on the larger scale. Objectives Over-hydration in diabetic ketoacidosis (DKA) may increase the risk of cerebral edema in children. Methods We have organized a prospective descriptive cohort study of 38pediatric patients aged 1month to 14 years, who were diagnosed with DKA with 41 episodes of diabetic ketoacidosis, presented to the pediatric emergency department at the First Affiliated Hospital of Xinjiang Medical University from January 2010 to February 2012. This study was approved by the Ethics Committee of The First Affiliated Hospital of Xinjiang Medical University. Results The magnitude presentation of the percentile 25% -70% was in the ratio of 5.6% (3.4% -8.2%) (6.1 ± 4) .So there was no clinical and biochemical assessment variation needed. These both of the variations, all of the diabetic ketoacidosis patient approached. Further all the patient variations were not correlated with the amplitude of variation and magnitude presentation and did not affect the fluid concentration and the quantity of the fluid was 47.8 mL / kg (36.556.3) in the first 12 hours. Conclusion For the conclusion of the exact parameters and the magnitude variations of the fluid in the patients of diabetic ketoacidosis, all of the conformations need study on the larger scale.